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KMID : 0360319920240040570
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Journal of Korean Cancer Research Association
1992 Volume.24 No. 4 p.570 ~ p.576
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Alternating Non-Cross-Resistant Chemotherapy with CAV(Cyclophosphamide, Adriamycin, Vincristine) and EP(Etoposide, Cisplatin) in Small Cell
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Abstract
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Fifty-three patients with small cell lung cancer were treated with chemotherapy consisting of cyclophosphamide, adriamycin, and vincristine(CAV) alternating with etoposide and cisplatin(EP). Thoracic radiotherapy was administered to the patients
with
limited stage disease. Prophylactic cranial irradiation with 30 Gy was applied to all complete responders.
Overall response rate was 66% with 32% of complete response. The response rate was 78% (CR 41%, PR 37%) in the patients with limited state disease, and 54%(CR 23%, PR 31%) in those with extensive stage disease. Patients with good performance
score(ECOG
0-1) showed higher response rate significantly(p=0.003).
Overall median survival was 8 months(2-37+). And the median survival in patients with CR, PR, and no response(SD and PD) were 12, 7.5,and 4 months, respectively(p<0.01).
These results suggest that alternating chemotherapy with CAV and EP may be useful as a treatment strategy in small cell lung cancer, but deserves more intensive randomized trials.
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KEYWORD
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